Oncology Clinical Trial Finder

Breast Cancer

Unknown status • Phase II • Stages III, IV • Medical Oncology • Post-Menopausal • Interventional

The following is imported from ClinicalTrials.gov:

An Open Label, Phase II Trial of Continuous Low-Irradiance Photodynamic Therapy (CLIPT) Using Verteporfin (Visudyne®) for the Treatment of Cutaneous Metastases of Breast Cancer

The purpose of this Phase II study is to evaluate the efficacy and safety of Continuous Low- Irradiance Photodynamic Therapy (CLIPT) when used with Verteporfin in the treatment of cutaneous metastases of breast cancer for which no curative or significantly palliative therapy exists, including chest wall therapy.

Breast Cancer

Study Design

Study type:


Estimated enrollment:

15 participants

Actual study start date:

October 20, 2016

Eligibility Criteria

Ages eligible for study:

18 - 999

Sexes eligible for study:


Arms and Intervention

  • Verteporfin

  • Continuous Low-Irradiance Photodynamic Therapy (CLIPT)

Inclusion criteria

  • Histologically or cytologically confirmed Stage IIIb or IV breast cancer with cutaneous metastases.

Exclusion criteria

  • Participants receiving any medications or substances that are known to cause photosensitivity (e.g. tetracyclines, sulfonamides, phenothiazines, sulfonylurea hypoglycemic agents, thiazide diuretics, griseofulvin, fluoroquinolones, St. Johns' wort, amiodarone) are ineligible.

  • Participants who have received prior systemic therapy (chemotherapy or targeted therapy) within 7 days of Study Day 1 or those who have not recovered from clinically significant adverse events due to agents administered more than 7 days earlier. (continuation of the same regimen of HER-2 antibody targeted therapy agents, hormonal therapy and treatment with bisphosphonates or denosumab are permitted)

  • Participants who are receiving any other investigational agents during the proposed treatment cycle.

Trial Information at Site

Last Updated:

Trial Information

ClinicalTrial.gov ID:

Unknown status

Estimated Enrollment:


Last Updated:


Site Contact

Steven J Isakoff, MD PhD


Massachusetts General Hospital

Boston, Massachusetts, United States, 02114

Trial Contacts

Steven J Isakoff, MD PhD

617 726 4920

Karleen Habin, RN

617 726 1922

Principal Investigator

Steven J Isakoff, MD PhD

Trial Sponsor

Rogers Sciences Inc.

Study Locations (2)

Dana Farber Cancer Institute

Boston, Massachusetts, United States

Massachusetts General Hospital

Boston, Massachusetts, United States


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